Tara Spires-Jones’ research focuses on the mechanisms and reversibility of neurodegeneration in Alzheimer’s disease, other degenerative brain diseases, and ageing. With a vibrant team of researchers, her work has shown that soluble forms of the pathological proteins amyloid beta and tau contribute to synapse and neurodegeneration, and that lowering levels of these proteins can ameliorate phenotypes in model systems. Her group has also discovered that pathological forms of tau spread through the brain via synaptic connections. Further, she has pioneered high-resolution imaging techniques in human post-mortem brain and found evidence that pathological proteins accumulate in synapses in human disease.

In addition to research, Professor Spires-Jones is passionate about communicating scientific findings to the public and policy makers; increasing the rigour and reproducibility in translational neuroscience; promoting inclusivity and diversity in science; and supporting career development of neuroscientists. She is President of the British Neuroscience Association (2023-2025).